Oritinib mesylate (SH-1028) is a highly selective, orally active, pyrimidine-based irreversible inhibitor of epidermal growth factor receptor (EGFR) with a low IC50 of 18 nM. It is effective against both EGFR-sensitive and resistant (T790M) mutations and suppresses the proliferation of tumor cells harboring EGFR mutations, irrespective of their sensitivity or resistance.
Molekulargewicht:
635.78
CAS Nummer:
[2180164-79-6]
Formel:
C32H41N7O5S
Target-Kategorie:
EGFR|||Others
T39670
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