TH5427 hydrochloride is a potent and selective inhibitor of NUDT5 with an IC50 of 29 nM. It demonstrates a remarkable 690-fold selectivity towards NUDT5 compared to MTH1. Moreover, TH5427 hydrochloride effectively inhibits progestin-dependent, PAR-derived nuclear ATP synthesis in breast cancer cells, thereby impeding chromatin remodeling, gene regulation, and ultimately suppressing proliferation.
Molekulargewicht:
527.79
CAS Nummer:
[2253744-57-7]
Formel:
C20H21Cl3N8O3
Target-Kategorie:
Others|||DNA/RNA Synthesis
T39785
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