Avatrombopag hydrochloride (AKR-501) is an orally active, nonpeptide agonist of the thrombopoietin (TPO) receptor with an EC50 of 3.3 nM. It effectively mimics TPO by stimulating platelet production through activation of the intracellular signaling system, facilitating platelet and megakaryocyte generation from hemopoietic precursor cells. Additionally, Avatrombopag hydrochloride serves as a substrate for cytochrome P450 [CYP] 2C9 and CYP3A.
Molekulargewicht:
686.11
CAS Nummer:
[570403-17-7]
Formel:
C29H35Cl3N6O3S2
Target-Kategorie:
Thrombopoietin Receptor|||Others
T40654
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