Moxonidine hydrochloride, CAS [[75536-04-8]] Preis auf Anfrage
Artikelnummer:
TGM-T40869
Hersteller Artikelnummer:
T40869
Alternativnummer:
TGM-T40869-50MG,TGM-T40869-100MG
Hersteller:
TargetMol
Kategorie:
Biochemikalien
Alternative Synonym:
BDF5895hydrochloride
Moxonidine Hydrochloride serves as a selective agonist for the imidazoline receptor subtype 1 and functions as an antihypertensive agent. It primarily acts within the central nervous system and demonstrates a significant preference for I1 imidazoline receptors over alpha2-adrenoceptors, with a 40-fold higher affinity. This compound effectively reduces stimulated norepinephrine overflow, indicating its potent efficacy. Despite similar agents like AGN192403 targeting the same receptor, moxonidines dose-response efficacy remains unaffected. Its ability to lower blood pressure and reduce heart rate is distinctly mediated through imidazoline receptors, reliant on well-preserved noradrenergic pathways within the rostral ventrolateral medulla (RVLM). This interaction is potentially linked to a specific 42 kDa imidazoline receptor protein, emphasizing its unique mechanism of action compared to other drugs like clonidine.
