FTI 277 TFA is a prodrug form of FTI 276 that inhibits farnesyltransferase (FTase) (IC50 = 0.5 nM). Inhibits H-Ras and K-Ras processing in whole cells (IC50 values are 0.1 and 10µM respectively) and disrupts constitutive H-Ras-specific activation of MAPK. Causes significant antiproliferative effects in human malignant glioma cells and many other tumor cell lines.
Molekulargewicht:
561.64
CAS Nummer:
[1217447-06-7]
Formel:
C24H30F3N3O5S2
Target-Kategorie:
Transferase|||Others|||Apoptosis|||Ras
T41212
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