GSK 2833503A is a potent and selective TRPC6 and TRPC3 antagonist (IC50 = 3-16 nM and 21-100 nM, respectively). GSK 2833503A exhibits >63-fold selectivity over other ion channels, including other TRP channels, CaV1.2, hERG and NaV1.5. GSK 2833503A suppresses angiotensin II or endothelin-1-induced cardiac hypertrophy signaling in HEK293 cellsin vitroand in cardiomyocytes.
Molekulargewicht:
381.9
CAS Nummer:
[1366234-01-6]
Formel:
C18H21ClFN3OS
Target-Kategorie:
Others|||TRP/TRPV Channel
T41232
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