Verrucarin A (Muconomycin A) is a Type D macrocyclic mycotoxin. Verrucarin A (VA), derived from the pathogen fungus Myrothecium verrucaria, is a protein synthesis inhibitor that inhibits the growth of leukemia cell lines and activates caspases, apoptosis, and inflammatory signaling in macrophages. It effectively increases the phosphorylation of p38 MAPK and diminishes the phosphorylation of ERK/Akt. Additionally, Verrucarin A causes cell cycle deregulation through the induction of p21 and p53 [1] [2].
Molekulargewicht:
502.55
CAS Nummer:
[3148-09-2]
Formel:
C27H34O9
Target-Kategorie:
Others|||Apoptosis|||ROS|||Reactive Oxygen Species
T41240
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