Tafamidis, CAS [[594839-88-0]]

Produktübersicht

• Artikelname: Tafamidis, CAS [[594839-88-0]]
• Artikelnummer: TGM-T4565
• Hersteller Artikelnummer: T4565
• Alternativnummer: TGM-T4565-1MLX10MM(INDMSO),TGM-T4565-5MG,TGM-T4565-10MG,TGM-T4565-25MG,TGM-T4565-50MG,TGM-T4565-100MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien
• Alternative Synonym: Fx-1006A

Produktbeschreibung

Tafamidis (Fx-1006A) is a kinetic stabilizer of transthyretin (TTR) that prevents amyloidogenesis by wild-type and mutant TTRs. It binds to TTR with negative cooperativity (Kd1: 3 nM, Kd2: 278 nM) to stabilize the TTR dimer-dimer interface and inhibit tetrameric dissociation. Tafamidis stabilizes wild-type and clinically significant V30M and V122I mutant TTR amyloidogenic homotetramers (EC50s: 2.7-3.2 µM) under fibril-promoting, denaturing, and physiological conditions in vitro. It stabilizes TTR heterotetramers containing wild-type and mutant subunits ex vivo in human plasma derived from patients carrying V30M or V1221 mutations when used at a concentration of 7.2 µM. Formulations containing tafamidis have been used for the treatment of familial amyloid polyneuropathy.

Produkteigenschaften

• Molekulargewicht: 308.12
• Reinheit: 0.9965
• CAS Nummer: [594839-88-0]
• Formel: C14H7Cl2NO3
• Target-Kategorie: Others

Bilder

T4565