RRD-251 is a specific small-molecule disruptor of the Rb-Raf-1 interaction. By blocking the physical binding between the Rb protein and Raf-1 kinase, it inhibits downstream cell cycle progression and survival signaling without affecting Rb-E2F1 binding. Research indicates that RRD-251 effectively induces apoptosis in various tumor cells, particularly metastatic melanoma, and demonstrates significant synergistic enhancement in combination chemotherapy studies.
Molekulargewicht:
271.59
Reinheit:
99.95%
CAS Nummer:
[72214-67-6]
Formel:
C8H9Cl3N2S
Target-Kategorie:
Raf
T60475
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
