ALK5-IN-8 is a highly effective inhibitor of TGFbetaRI (ALK5). It hinders the phosphorylation of ALK5 on downstream signaling proteins (Smad2 or Smad3) by obstructing the interaction between TGFbetaRI and ligands. Consequently, it disrupts or prevents TGF-beta signaling. ALK5-IN-8 shows promise in the study of diverse diseases associated with ALK5-mediated pathways[1].
Molekulargewicht:
350.35
CAS Nummer:
[2705900-81-6]
Formel:
C19H15FN4O2
Target-Kategorie:
Others|||TGF-beta/Smad
T61203
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