SRI-41315 is an eRF1 degrader that acts as a molecular glue at the center of ribosomal decoding.SRI-41315 induces an extended pause at the termination codon and inhibits cystic fibrosis-associated PTC in immortalized and primary human bronchial epithelial cells, restoring CFTR expression and function.SRI-41315 inhibits PTC by decreasing the abundance of the termination factor eRF1 NIOCH 14
Molekulargewicht:
357.41
Reinheit:
99.87%
CAS Nummer:
[1613509-49-1]
Formel:
C22H19N3O2
Target-Kategorie:
CFTR
T61306
T61306
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