Fasudil dihydrochloride, also known as HA-1077 and AT877, is a nonspecific inhibitor of RhoA/ROCK. Fasudil dihydrochloride exhibits inhibitory effects on protein kinases including ROCK1 (Ki = 0.33 µM), ROCK2 (IC50 = 0.158 µM), PKA (IC50 = 4.58 µM), PKC (IC50 = 12.30 µM), and PKG (IC50 = 1.650 µM), while also acting as a potent Ca2+ channel blocker and vasodilator, providing a multifunctional pharmacological tool for vascular, cardiovascular, and cellular signaling research.
Molekulargewicht:
364.29
Reinheit:
99.86%
CAS Nummer:
[203911-27-7]
Formel:
C14H19Cl2N3O2S
Target-Kategorie:
ROCK|||Rho|||PKA|||PKC
T61382
T61382
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