D18 is an immune modulator that acts as a dual agonist for TLR7/8 (with EC50 values of 24 nM for hTLR7 and 10 nM for hTLR8, respectively). It enhances the expression of PD-L1 through epigenetic regulation, thereby increasing the sensitivity of tumors to PD-1/PD-L1 blockade. Additionally, D18 functions as a cytotoxin for ADC synthesis, specifically for the ADC HE-S2 [1].
Molekulargewicht:
364.49
CAS Nummer:
[2230218-36-5]
Formel:
C21H28N6
Target-Kategorie:
Others|||PD-1/PD-L1|||TLR
T61390
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