NMDAR/HDAC-IN-1 (Compound 9d) is a potent dual inhibitor of N-methyl-D-aspartate receptors (NMDARs) and histone deacetylases (HDACs), with a high affinity for NMDARs (Ki = 0.59 µM) and significant inhibitory effects on various HDAC isoforms, including HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 with IC50 values of 2.67 µM, 8.00 µM, 2.21 µM, 0.18 µM, and 0.62 µM, respectively, additionally, it efficiently crosses the blood-brain barrier [1].
Molekulargewicht:
368.47
Formel:
C22H28N2O3
Target-Kategorie:
Others|||HDAC|||iGluR
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
