AAK1-IN-5 is a potent and specific inhibitor of adaptor protein-2-associated kinase 1 (AAK1), characterized by its ability to penetrate the central nervous system and its oral bioavailability. It displays high selectivity, with an AAK1 inhibitory potency (IC 50) of 1.2 nM, a binding affinity (K i) of 0.05 nM, and an inhibitory potency against cellular AAK1 activity (cell IC 50) of 0.5 nM. AAK1-IN-5 holds promise for investigating neuropathic pain in scientific research [1].
Molekulargewicht:
385.4
CAS Nummer:
[1815613-44-5]
Formel:
C19H23F4N3O
Target-Kategorie:
Others|||AAK1 (AP2 associated kinase 1)
T61693
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