Anticancer agent 82 is a FiVe1 derivative, an orally active and selective anticancer agent. FiVe1 binds type III intermediate filament protein vimentin ( VIM ), to induce hyperphosphorylation of Ser56, resulting selective disruption of mitosis and multinucleation in transformed VIM-expressing mesenchymal cancer cells. Anticancer agent 82 shows better oral bioavailability and pharmacokinetic profiles than FiVe1 [1].
Molekulargewicht:
389.28
CAS Nummer:
[2319587-80-7]
Formel:
C19H18Cl2N4O
Target-Kategorie:
Others|||Proteasome
T61746
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