HDAC-IN-47 is an orally active histone deacetylase (HDAC) inhibitor, with IC50 values of 19.75 nM, 57.8 nM, 40.27 nM, 5.63 nM, and 302.73 nM for HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8, respectively. HDAC-IN-47 can block the cell cycle in the G2/M phase, inhibit autophagy, induce apoptosis via the Bax/Bcl-2 and caspase-3 pathways, and exhibits anti-cancer activity in vivo.
Molekulargewicht:
410.26
Formel:
C17H20BrN3O4
Target-Kategorie:
Others|||HDAC
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
