MYF-03-176 is an orally active TEAD1/3/4 inhibitor with IC50 values of 47/32/71 nM, respectively. It also inhibits TEAD transcriptional activity and cell growth in NCI-H226 cells, exhibiting antitumour activity in malignant pleural mesothelioma (MPM) cells with defective Hippo signalling and in mouse xenograft models.
Molekulargewicht:
410.37
Reinheit:
99.72%
CAS Nummer:
[2857937-59-6]
Formel:
C19H18F4N4O2
Target-Kategorie:
YAP
T62074
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