SKLB-197 is a potent and highly selective inhibitor of ataxia telangiectasia and Rad3-related kinase (ATR) with an IC50 value of 0.013 µM and minimal activity against more than 402 other kinases. SKLB-197 shows strong antitumor efficacy in ATM-deficient tumors both in vitro and in vivo, while also exhibiting favorable pharmacokinetic properties for oncology research.
Molekulargewicht:
424.5
Reinheit:
99.53%
CAS Nummer:
[2713577-16-1]
Formel:
C25H24N6O
Target-Kategorie:
ATM/ATR
T62290
T62290
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