FLT3-IN-12 is a selective, potent, orally active FLT3 kinase inhibitor that acts on FLT3-WT (IC50: 1.48 nM) and FLT3-D835Y (IC50: 2.87 nM). FLT3-IN-12 is more selective than c-KIT (>1000-fold). FLT3-IN-12 showed significant anti-AML effects, with an IC50 value of 0.75 nM for MV4-11 cells.
Molekulargewicht:
432.44
CAS Nummer:
[2499966-67-3]
Formel:
C21H23F3N6O
Target-Kategorie:
Others|||FLT
T62412
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