KRAS inhibitor-12 (compound 6-1) is a potent inhibitor of KRAS G12C (IC50: 0.537 µM), exhibiting p-ERK inhibition in MIA PaCA-2 and A549 cells with IC50 values of 1.3 and 3.7 µM, respectively. KRAS inhibitor-12 has potential for study in pancreatic, colorectal, and lung cancers.
Molekulargewicht:
452.33
CAS Nummer:
[2230874-00-5]
Formel:
C19H16Cl2FN5OS
Target-Kategorie:
Others|||Ras|||Kras
T62751
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