KRAS inhibitor-16 (compound 3-11) is a potent inhibitor of KRAS G12C (IC50: 0.457 µM) and exhibits p-ERK inhibition in MIA PaCA-2 and A549 cells with IC50s of 3.06 and 11.1 µM, respectively. KRAS inhibitor-16 has potential for study in pancreatic, colorectal, and lung cancers.
Molekulargewicht:
452.33
CAS Nummer:
[2230873-67-1]
Formel:
C20H16Cl2FN3O2S
Target-Kategorie:
Others|||Ras|||Kras
T62752
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