KRAS inhibitor-18 (compound 3-10) is a potent inhibitor of KRAS G12C (IC50: 4.74 µM) and exhibited p-ERK inhibition in MIA PaCA-2 and A549 cells with IC50s of 66.4 µM and 11.1 µM, respectively. KRAS inhibitor-18 has potential for pancreatic, colorectal, and lung cancer studies.
Molekulargewicht:
453.87
CAS Nummer:
[2230873-66-0]
Formel:
C20H15ClF3N3O2S
Target-Kategorie:
Others|||Kras|||Ras
T62784
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