PRMT5 IN-1 hydrochloride (compound 9) is a hemiacetalamine and a potent inhibitor of selective protein arginine methyltransferase 5 (PRMT5), exhibiting an inhibitory effect on PRMT5/MEP50 with an IC50 of 11 nM. Under physiological conditions, it can be converted to an aldehyde and reacts with C449 to form a covalent adduct.
Molekulargewicht:
455.29
Formel:
C19H20Cl2N4O5
Target-Kategorie:
Histone Methyltransferase|||Others
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