HOIPIN-8 is a potent inhibitor of the linear ubiquitin chain assembly complex (LUBAC) with an IC50 of 11 nM. As a derivative of HOIPIN-1, it exhibits 255-fold greater inhibition of both petit-LUBAC and TNF-alpha-mediated NF-kappaB activation compared to HOIPIN-1. HOIPIN-8 is a promising tool to explore cellular functions of LUBAC.
Molekulargewicht:
456.38
Reinheit:
97.34%
CAS Nummer:
[2519537-70-1]
Formel:
C23H15F2N4NaO3
Target-Kategorie:
E1/E2/E3 Enzyme|||IkappaB/IKK
T62826
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