LPA5 antagonist 2 is a highly water-soluble, selective antagonist of the lysosomal phosphatidic acid receptor 5 (LPA5) that inhibits downstream calcium mobilization (IC50 = 69 nM) and cAMP signaling (IC50 = 340 nM) by blocking the binding of its natural ligand, LPA. LPA5 antagonist 2 significantly alleviates CFA-induced inflammatory pain and nociceptive hypersensitivity and can be used in research related to inflammatory and neuropathic pain.
Molekulargewicht:
480.55
Reinheit:
99.82%
CAS Nummer:
[2839471-44-0]
Formel:
C26H25FN2O4S
Target-Kategorie:
LPL Receptor
T63172
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