EGFR-IN-47 (compound 14aj) is a potent, fourth-generation, and orally active EGFR inhibitor. It specifically targets the EGFR L858R/T790M/C797S triple mutation with an IC50 of 0.01 uM. In NSCLC research, EGFR-IN-47 effectively overcomes C797S-mediated resistance to Osimertinib by inhibiting the phosphorylation of EGFR and its downstream mediators, subsequently inducing cell cycle arrest and apoptosis.
Molekulargewicht:
481.64
Reinheit:
98.78%
CAS Nummer:
[3034649-73-2]
Formel:
C29H35N7
Target-Kategorie:
EGFR
T63185
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
