COX-2-IN-22 is a COX-2 inhibitor (IC50: 8.6 µM) that can cross the blood-brain barrier and also exhibits inhibitory effects on AChE (IC50: 2.8 µM), BChE (IC50: 6.3 µM), beta-Secretase (IC50: 15.3 µM), LOX-5 (IC50: 13.9 µM) and DPPH ( IC50: 6.8 µM) showed inhibitory effects.