KRAS inhibitor-14 is a potent inhibitor of KRAS G12C (IC50: 0.249 µM). KRAS inhibitor-14 exhibited p-ERK inhibition in MIA PaCA-2, A549 cells with IC50s of 1.12, >33.3 µM, respectively. KRAS inhibitor-14 has potential to be investigated in pancreatic, colorectal and lung cancers.
Molekulargewicht:
486.77
CAS Nummer:
[2230873-78-4]
Formel:
C20H15Cl3FN3O2S
Target-Kategorie:
Others|||Kras|||Ras
T63235
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