HDAC/HSP90-IN-3 is a selective and potent dual inhibitor of fungal Hsp90 (IC50: 0.83 µM) and HDAC (IC50: 0.91 µM), exhibiting antifungal effects against azole-resistant Candida albicans. HDAC/HSP90-IN-3 exhibits inhibitory effects on important virulence factors and is able to downregulate the resistance genes ERG11 and CDR1.
Molekulargewicht:
511.57
CAS Nummer:
[2700035-54-5]
Formel:
C26H33N5O6
Target-Kategorie:
Antifungal|||HDAC|||Others|||HSP
T63529
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