G12Si-1 is a selective, covalent K-Ras(G12S) inhibitor that inhibits K-Ras(G12S) oncogenic signaling. On mutant serine residues, G12Si-1 binds K-Ras(G12S) well.G12Si-1 may also be able to impede Sos-catalyzed exchange and inhibit EDTA-facilitated exchange rates, thereby affecting the nucleotide cycle of K-Ras.
Molekulargewicht:
534.05
Formel:
C29H32ClN5O3
Target-Kategorie:
Others|||Ras
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
