Safusidenib is a selective, orally active mutant inhibitor of IDH1 that significantly inhibits mutant IDH1, but not wild-type IDH1, and inhibits tumor activity in chondrosarcoma. safusidenib is active against IDH1R132H and IDH1R132C, and in the absence of preincubation, the IC50 values were 15 and 130 nM, respectively.
Molekulargewicht:
535.78
CAS Nummer:
[1898206-17-1]
Formel:
C25H18Cl3FN2O4
Target-Kategorie:
Others|||Isocitrate Dehydrogenase (IDH)
T63778
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