Ro 31-8220 is a potent inhibitor of PKC with IC50 values of 5, 24, 14, 27, 24, and 23 nM for PKCalpha, PKCbetaI, PKCbetaII, PKCgamma, PKCepsilon, and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1, and GSK3beta with IC50 values of 3, 8, 15, and 38 nM, respectively, without affecting MKK3, MKK4, MKK6, and MKK7.
Molekulargewicht:
457.55
CAS Nummer:
[125314-64-9]
Formel:
C25H23N5O2S
Target-Kategorie:
JNK|||PKC|||Others
T6643L
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