BMS-214662 hydrochloride is a Farnesyltransferase inhibitor , is also a nonsedating benzodiazepine derivative with potential antineoplastic activity. BMS-214662 hydrochloride inhibits the enzyme farnesyltransferase and the post-translational farnesylation of number of proteins involved in signal transduction, which may result in the inhibition of Ras function and apoptosis in susceptible tumor cells. This agent may reverse the malignant phenotype of H-Ras-transformed cells and has been shown to be active against tumor cells with and without Ras mutations.
Molekulargewicht:
526.07
CAS Nummer:
[195981-08-9]
Formel:
C25H24ClN5O2S2
Target-Kategorie:
Ras|||Others|||Transferase
T68227
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