AKI-001, CAS [[925218-37-7]]

Produktübersicht

• Artikelname: AKI-001, CAS [[925218-37-7]]
• Artikelnummer: TGM-T68332
• Hersteller Artikelnummer: T68332
• Alternativnummer: TGM-T68332-25MG,TGM-T68332-50MG,TGM-T68332-100MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien

Produktbeschreibung

AKI-001 is a potent Aurora kinase inhibitor, which exhibits low nanomolar potency against both Aurora A and Aurora B enzymes, excellent cellular potency (IC50 < 100 nM), and good oral bioavailability. Phenotypic cellular assays show that both Aurora A and Aurora B are inhibited at inhibitor concentrations sufficient to block proliferation. Importantly, the cellular activity translates to potent inhibition of tumor growth in vivo. An oral dose of 5 mg/kg QD is well tolerated and results in near stasis (92% TGI) in an HCT116 mouse xenograft model.

Produkteigenschaften

• Molekulargewicht: 348.44
• CAS Nummer: [925218-37-7]
• Formel: C21H24N4O
• Target-Kategorie: Others

Bilder

T68332