HS56 is an ATP-competitive dual Pim/DAPK3 inhibitor, displaying K_i values of 0.26 µM for DAPK3, 0.208 µM for Pim-3, 2.94 µM for Pim-1, and >100 µM for Pim-2. This compound effectively inhibits LC20 phosphorylation and smooth muscle contraction, and reduces blood pressure in spontaneously hypertensive mice, making it a valuable tool for hypertension research [HS-56].
Molekulargewicht:
317.75
CAS Nummer:
[922050-57-5]
Formel:
C13H8ClN5OS
Target-Kategorie:
Pim|||Others|||DAPK
T68341
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