Blapsin B is a potent 14-3-3 inhibitor. Blapsin B is a naturally occurring compound isolated from the ethanol extract of the stink beetle, Blaps japanensis. Blapsin B potently inhibited 14-3-3 protein-protein interactions (PPIs) with IC(50) value of 10.0 µM as determined by an ELISA assay, and 2.5 µM in an FP assay, respectively. Blapsin B represent the first example of natural small-molecule 14-3-3 inhibitors.
Molekulargewicht:
274.27
CAS Nummer:
[861145-00-8]
Formel:
C15H14O5
Target-Kategorie:
Others
T68529
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