Dextrallorphan (DXA) is an chemical of the morphinan class that is used in scientific research. It acts as a sigma1 receptor agonist and NMDA receptor antagonist. It has no significant affinity for the sigma2, µ-opioid, or delta-opioid receptor, or for the serotonin or norepinephrine transporter. As an NMDA receptor antagonist, in vivo, it is approximately twice as potent as dextromethorphan, and five-fold less potent than dextrorphan. Dextrallorphan was found to have a half maximal inhibitory concentration (IC50) for binding to the pituitary and brain receptor of 10,000 1000 nM and 10,000 1500 nM, respectively. While its stereoisomer, levallorphan, had a 10,000 times more potent dose, thus proving that binding to these receptors is stereospecific.
Molekulargewicht:
283.41
CAS Nummer:
[5822-43-5]
Formel:
C19H25NO
Target-Kategorie:
Others
T69060
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