CK0106023 was specific inhibitor of KSP. In tumor-bearing mice, CK0106023 exhibited antitumor activity comparable to or exceeding that of paclitaxel and caused the formation of monopolar mitotic figures identical to those produced in cultured cells. KSP was most abundant in proliferating human tissues and was absent from cultured postmitotic neurons.
Molekulargewicht:
595.96
CAS Nummer:
[336115-72-1]
Formel:
C30H32BrClN4O2
Target-Kategorie:
Others|||Kinesin
T69415
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