CLE-030 is a KCNQ2 agonist. CLE030 stably binds to the central cavity. Functional analysis, molecular dynamics simulations, and calculations of the potential of mean force revealed that the carbonyl oxygen of CLE030 influences permeant ions in the central cavity to contribute to its activation effects.
Molekulargewicht:
556.34
CAS Nummer:
[2803111-66-0]
Formel:
C20H20Br2N4OS2
Target-Kategorie:
Others
T69514
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