Isoproterenol-d7 is intended for use as an internal standard for the quantification of isoproterenol by GC- or LC-MS. Isoproterenol is an agonist of beta1- and beta2-adrenergic receptors (beta1- and beta2-ARs, Kis = 224 and 458 nM, respectively). It is selective for beta1- and beta2-ARs over beta3-ARs (Ki = 1,570 nM). Isoproterenol inhibits contractions in isolated field-stimulated rat vas deferens (EC50 = 45.6 nM). In vivo, isoproterenol (0.33 mg/kg) decreases blood pressure and increases water intake in nephrectomized rats. It reduces blood pressure and increases heart rate in renal hypertensive rabbits. Isoproterenol inhibits histamine-induced bronchospasms in anesthetized dogs. Formulations containing isoproterenol have been used in the treatment of bradydysrhythmias and to improve breathing during anesthesia.
Molekulargewicht:
254.76
CAS Nummer:
[2517584-04-0]
Formel:
C11H18ClNO3
Target-Kategorie:
Endogenous Metabolite|||Adrenergic Receptor
T69598
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