SR-1903 is a modulator of retinoic acid receptor-related orphan receptor gamma (RORgamma) and liver X receptor (LXR). It is an inverse agonist of RORgamma and an agonist of LXR. It also binds to peroxisome proliferator-activated receptor gamma (PPAR) but does not activate it. SR-1903 inhibits LPS-induced expression of triggering receptor expressed on myeloid cells 1 (TREM-1). It also inhibits LPS-induced expression of the LXR target genes IL-6 and IL-33 and increases expression of ABCG1, FASN, and SCD-1. SR-1903 reduces the severity of collagen-induced arthritis. It reduces blood glucose levels in a glucose tolerance test, serum levels of total cholesterol and LDL, body weight, and fat mass in a mouse model of high-fat diet-induced obesity.
Molekulargewicht:
637.54
CAS Nummer:
[2351884-03-0]
Formel:
C29H28F9N3O3
Target-Kategorie:
Others
T69671
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