AEW541 HCl, CAS [[2320261-63-8]]

Produktübersicht

• Artikelname: AEW541 HCl, CAS [[2320261-63-8]]
• Artikelnummer: TGM-T69682
• Hersteller Artikelnummer: T69682
• Alternativnummer: TGM-T69682-1MG,TGM-T69682-5MG,TGM-T69682-10MG,TGM-T69682-500UG
• Hersteller: TargetMol
• Kategorie: Biochemikalien

Produktbeschreibung

AEW541, also known as NVP-AEW541, is a novel, potent IGF-IR kinase inhibitor. NVP-AEW541 is capable of distinguishing between the IGF-IR (IC50 = 0.086 microM) and the closely related InsR (IC50 = 2.3 microM) in cells. NVP- AEW541 abrogates IGF-I-mediated survival and colony formation in soft agar at concentrations that are consistent with inhibition of IGF-IR autophosphorylation. Note: AEW541 has a Cis-configuration on the cyclobutane ring. Its CAS is 475489-16-8. Many vendors and Sc-finder scholar made mistake - AEW541 was mistakenly listed as CAS475488-34-7, the trans-isomer of AEW541. The correct structure of AEW541 can be confirmed from Joel Slade, et al (from Novartis), Org. Process Res. Dev. 2007, 11, 5, 825-835.

Produkteigenschaften

• Molekulargewicht: 512.47
• CAS Nummer: [2320261-63-8]
• Formel: C27H31Cl2N5O
• Target-Kategorie: Others|||IGF-1R|||Autophagy

Bilder

T69682