MS-177 is a PROTAC EZH2 degrader that promotes cholangiocarcinoma growth through the EZH2-mediated WNT7B/beta-catenin pathway.MS-177 inhibits the growth of leukemia cells, induces apoptosis, and cell cycle arrest.MS-177 induces degradation of the classical EZH2-PRC2 and the non-classical EZH2-cMyc complexes and activates the immune-responsive genes in MM cells.
Molekulargewicht:
914.02
CAS Nummer:
[2225938-86-1]
Formel:
C48H55N11O8
Target-Kategorie:
PROTACs|||Apoptosis|||Histone Methyltransferase
T69771
T69771
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