USP7-IN-4(USP7 inhibitor ALM4) is a non-competitive, potent and selective inhibitor of USP7 (ubiquitin-specific protease 7) with an IC50 = 6 nM, up-regulates p53 and p21, down-regulates MDM2, increases the level of ubiquitination of MDM2, and exhibits anti-proliferative activity in a variety of cancer cell lines, with an EC50 = 2.0 nM in RS4,11 (acute lymphoblastic leukemia cell line) .
Molekulargewicht:
514.62
Reinheit:
>99.99%
CAS Nummer:
[2196243-57-7]
Formel:
C29H34N6O3
Target-Kategorie:
p53|||MDM-2/p53|||DUB
T69820
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