NG25 trihydrochloride, CAS [[2108554-00-1]]

Produktübersicht

• Artikelname: NG25 trihydrochloride, CAS [[2108554-00-1]]
• Artikelnummer: TGM-T69898
• Hersteller Artikelnummer: T69898
• Alternativnummer: TGM-T69898-25MG,TGM-T69898-50MG,TGM-T69898-100MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien

Produktbeschreibung

NG25 trihydrochloride is a type II kinase inhibitor that inhibits MAP4K2 and TAK1. It also inhibits the Src family kinases Src and LYN and Abl family kinases as well as CSK, FER, and p38alpha. NG 25 prevents TNF-alpha-induced IKKalpha/beta phosphorylation and IkappaB-alpha degradation in L929 cells. It inhibits secretion of IFN-alpha and IFN-beta induced by CpG type B and CL097, respectively. NG 25 decreases cell viability of HCT116KRASWT, and to a greater degree of HCT116KRASG13D, colorectal cancer cells in a concentration-dependent manner. It also reduces tumor growth and increases the number of TUNEL-positive tumor cells in a CT26KRASG12D mouse orthotopic model of colorectal cancer.

Produkteigenschaften

• Molekulargewicht: 646.96
• CAS Nummer: [2108554-00-1]
• Formel: C29H33Cl3F3N5O2
• Target-Kategorie: Others|||Ras|||MAPK|||Kras

Bilder

T69898