1. Linarin (Acacetin-7-O-rutinoside) (acacetin-7-O-beta-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviates GalN/LPS-induced liver injury by suppressing TNF-alpha-mediated apoptotic pathways. 3. Linarin prevents A beta-induced neurotoxicity through the activation of PI3K/Akt, which subsequently inhibits GSK-3b and up-regulates Bcl-2. 4. The piperine significantly enhanced the oral absorption of Linarin in rats by inhibiting P-glycoprotein mediated cellular efflux during the intestinal absorption and likely simultaneously by inhibiting the metabolism of Linarin.
Molekulargewicht:
592.55
Reinheit:
97.81%
CAS Nummer:
[480-36-4]
Formel:
C28H32O14
Target-Kategorie:
TNF|||Cholinesterase (ChE)
T6S0653
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