Roridin E inhibits the receptor tyrosine kinases FGFR3, IGF-1R, PDGFRbeta, and TrkB (IC50s = 0.4, 0.4, 1.4, and 1 µM, respectively) and induces cytotoxicity in multiple breast cancer cell lines (IC50s = 0.02-0.05 nM). It also inhibits proliferation in a panel of additional cancer cell lines (IC50s = <0.01 µM).
Molekulargewicht:
514.61
CAS Nummer:
[16891-85-3]
Formel:
C29H38O8
Target-Kategorie:
Antibiotic|||Others|||Antifungal
T70276
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