AMG151 HCl, CAS [[1609674-80-7]]

Produktübersicht

• Artikelname: AMG151 HCl, CAS [[1609674-80-7]]
• Artikelnummer: TGM-T70391
• Hersteller Artikelnummer: T70391
• Alternativnummer: TGM-T70391-25MG,TGM-T70391-50MG,TGM-T70391-100MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien

Produktbeschreibung

ARRY-403, also known as AMG-151, is an orally available allosteric glucokinase (GK) activator developed for the treatment of type 2 diabetes mellitus (T2DM). ARRY-403 has many favorable physicochemical characteristics and ADME properties (low potential to cause drug-drug interactions (DDIs). ARRY-403 potently activates human glucokinase (GK) in vitro (EC50 = 79 nM at 5 mM glucose), with an S0.5 = 0.93 mM glucose (ARRY-403 at 5 mM) and Vmax = 134% compared to the no activator control. It possesses good in vitro drug-like properties (aqueous solubility, cell permeability, low low potential for drug-drug interactions, low predicted hepatic clearance), and selectivity against broad panels of receptors and enzymes.

Produkteigenschaften

• Molekulargewicht: 527.439
• CAS Nummer: [1609674-80-7]
• Formel: C20H20Cl2N6O3S2
• Target-Kategorie: Others

Bilder

T70391