GW841819X is an analogue of (+)-JQ1 and a novel inhibitor of BET bromodomains. GW841819X displayed activity in vivo against NUT-midline carcinoma, multiple myeloma, mixed-lineage leukemia, and acute myeloid leukemia. Bromodomain and extra-terminal (BET) proteins belong to a class of proteins collectively called epigenetic readers. BET bromodomains have emerged as promising drug targets for treatment of cancers
Molekulargewicht:
423.47
CAS Nummer:
[146135-18-4]
Formel:
C25H21N5O2
Target-Kategorie:
Epigenetic Reader Domain|||Others
T70593
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